Schwartz Marianne, Vissing John
Department of Clinical Genetics, National University Hospital, Rigshospitalet, Copenhagen, Denmark.
Biochem Biophys Res Commun. 2003 Oct 17;310(2):247-51. doi: 10.1016/j.bbrc.2003.09.037.
With the identification of a patient with mutated mitochondrial DNA (mtDNA) of paternal origin, it has been unequivocally proven that not only does paternal mtDNA survive in the zygote, but it can also contribute substantially to the mtDNA pool of adult, human skeletal muscle. The questions are: how often does paternal mtDNA inheritance occur and what mechanisms are involved? In this paper, we will review current knowledge on the fate of sperm mitochondria after fertilization and discuss the impact paternal inheritance may have on our understanding of mitochondrial biology.
随着一名父源线粒体DNA（mtDNA）发生突变的患者被鉴定出来，已经明确证实，父源mtDNA不仅能在受精卵中存活，而且还能对成年人类骨骼肌的mtDNA库做出重大贡献。问题是：父源mtDNA遗传的发生频率如何，涉及哪些机制？在本文中，我们将回顾受精后精子线粒体命运的现有知识，并讨论父源遗传可能对我们理解线粒体生物学产生的影响。
