Maccaferri Gianmaria, Lacaille Jean-Claude
Feinberg School of Medicine, Department of Physiology, Northwestern University, Chicago, IL 60611, USA.
Trends Neurosci. 2003 Oct;26(10):564-71. doi: 10.1016/j.tins.2003.08.002.
The nervous system is made up of many specific types of neuron intricately intertwined to form complex networks. Identifying and defining the characteristic features of the many different neuronal types is essential for achieving a cellular understanding of complex activity from perception to cognition. So far, cortical GABAergic interneurons have represented the epitome of cellular diversity in the CNS. Despite the desperate need for effective classification criteria allowing a common language among neuroscientists, interneurons still evoke memories of Babel. Several approaches are now available to overcome the challenges and problems associated with the various classification systems used so far.
神经系统由许多特定类型的神经元错综复杂地交织在一起，形成复杂的网络。识别和定义许多不同神经元类型的特征，对于从感知到认知的复杂活动实现细胞层面的理解至关重要。到目前为止，皮质GABA能中间神经元代表了中枢神经系统中细胞多样性的缩影。尽管迫切需要有效的分类标准，以便神经科学家之间有共同的语言，但中间神经元仍然让人想起巴别塔的故事。现在有几种方法可以克服与迄今为止使用的各种分类系统相关的挑战和问题。
