Shah P R, Ramakrishna B, Mehta D K, Shah R C
Department of Pediatrics, B.J. Medical College and Civil Hospital, Ahmedabad.
Indian J Pediatr. 1992 Jul-Aug;59(4):435-42. doi: 10.1007/BF02751558.
Five hundred children below the age of 12 years suffering from lung tuberculosis viz., primary complex (PC) or progressive primary complex (PPC) were studied. Diagnosis was based on Kenneth Jones criteria; selected cases having score of 5 or more. One hundred and eighty cases of PC were given A-1 (6 RH) regimen, while 312 cases of PPC were given A-2 (2SHRZ/4 RH) or A-3 (2 SRH/4 RH) or A-4 (2 RHE/4 RH) regimen. Follow-up was done for 6 months after completing the treatment to observe the relapse rate. In cases of PC, 6 RH regimen appeared adequate and cheaper with no relapse rate. In cases of PPC with short course chemotherapy, compliance of patients had been very good. Relapse rate was up to 13% which is acceptable. Drug toxicity was very low.
对500名12岁以下患有肺结核(即原发综合征(PC)或进展性原发综合征(PPC))的儿童进行了研究。诊断依据肯尼斯·琼斯标准;所选病例得分在5分及以上。180例PC患者接受A-1(6RH)方案治疗,而312例PPC患者接受A-2(2SHRZ/4RH)或A-3(2SRH/4RH)或A-4(2RHE/4RH)方案治疗。治疗结束后进行6个月的随访以观察复发率。在PC病例中,6RH方案似乎足够且费用较低,无复发率。在PPC的短程化疗病例中,患者的依从性非常好。复发率高达13%,这是可以接受的。药物毒性非常低。