Will Robert G
National CJD Surveillance Unit, Department of Clinical Neuroscience, Western General Hospital, Edinburgh, UK.
Br Med Bull. 2003;66:255-65. doi: 10.1093/bmb/66.1.255.
Human prion diseases can be classified as sporadic, hereditary or acquired. The cause of sporadic Creutzfeldt-Jakob disease (CJD) is unknown, hereditary cases are associated with mutations of the prion protein gene (PRNP) and acquired forms are caused by the transmission of infection from human to human or, as a zoonosis, from cattle to human. Although acquired forms of human prion disease are rare, the transmission of a fatal and untreatable neurological disorder has had major implications for public health and public policy.
人类朊病毒病可分为散发性、遗传性或获得性。散发性克雅氏病（CJD）的病因尚不清楚，遗传性病例与朊病毒蛋白基因（PRNP）突变有关，获得性形式是由人与人之间的感染传播引起的，或者作为人畜共患病，由牛传播给人。虽然获得性人类朊病毒病形式罕见，但一种致命且无法治疗的神经疾病的传播对公共卫生和公共政策产生了重大影响。
