Williams T N, Wonke B, Donohue S M
Department of Hematology, Whittington Hospital, London.
Indian Pediatr. 1992 Sep;29(9):1119-24.
A series of clinics were conducted in Delhi, India, in January, 1990. Of 54 patients with beta thalassemia major (mean age 7.6 years), 11.1% (6 out of 54) tested positive for antibodies to hepatitis C virus (anti HCV antibodies) and 66.6% (36 out of 54) showed evidence of hepatitis B virus (HBV) infection. Only 7.4% (4 out of 54) were hepatitis B surface antigen (HBsAg) positive. Of their parents, 2.2% (2 out of 90) tested positive for anti HCV antibodies, 28.9% (26 out of 90) showed evidence of previous HBV infection and 11.1% (10 out of 90) were HBsAg positive. We argue that HCV constitutes a greater long term threat than HBV in these patients due to the higher incidence of chronic liver disease. We would advocate the introduction of HCV screening of donated blood as well as reinforcing the importance of HBV screening and immunization.
1990年1月，在印度德里开展了一系列门诊。在54例重型β地中海贫血患者（平均年龄7.6岁）中，11.1%（54例中的6例）丙肝病毒抗体（抗HCV抗体）检测呈阳性，66.6%（54例中的36例）有乙肝病毒（HBV）感染证据。仅7.4%（54例中的4例）乙肝表面抗原（HBsAg）呈阳性。其父母中，2.2%（90例中的2例）抗HCV抗体检测呈阳性，28.9%（90例中的26例）有既往HBV感染证据，11.1%（90例中的10例）HBsAg呈阳性。我们认为，由于慢性肝病发病率较高，在这些患者中，丙肝病毒比乙肝病毒构成的长期威胁更大。我们主张对献血进行丙肝病毒筛查，并强化乙肝病毒筛查和免疫接种的重要性。
