Jacobs R, Dodgson K S, Richards R J
Br J Exp Pathol. 1977 Oct;58(5):541-8.
Changes are reported in the DNA, RNA, protein and brush border enzymes in the small intestine mucosal lining cells and gut lumen, induced by maintaining rats on a diet containing chrysotile asbestos for 10 months. Intracellular levels of RNA, DNA and protein remained unchanged but significant alterations, consistent with a mineral-induced cytotoxicity, were found in the lumen level of DNA (increased) and RNA (decreased) in asbestos-treated rats. Most intracellular enzyme levels were consistently, but not significantly, elevated in animals maintained on diets containing asbestos whilst the activities within the lumen were significantly higher than those found in normal animals. The presence of cigarette smoke alone in the diet induced changes in intracellular RNA and lumen ATPase but the combined effect of cigarette smoke and asbestos was rarely different from the alterations induced by asbestos alone on the majority of parameters studied.
据报道，给大鼠喂食含温石棉的饮食10个月，可诱导小肠黏膜衬里细胞和肠腔中的DNA、RNA、蛋白质及刷状缘酶发生变化。细胞内RNA、DNA和蛋白质水平保持不变，但在石棉处理的大鼠中，肠腔水平的DNA（增加）和RNA（减少）出现了与矿物诱导的细胞毒性一致的显著变化。在喂食含石棉饮食的动物中，大多数细胞内酶水平持续升高，但无显著差异，而肠腔内的酶活性明显高于正常动物。饮食中单独存在香烟烟雾会诱导细胞内RNA和肠腔ATP酶发生变化，但在大多数研究参数上，香烟烟雾和石棉的联合作用与单独石棉诱导的变化几乎没有差异。
