Katzmarzyk Peter T, Leon Arthur S, Wilmore Jack H, Skinner James S, Rao D C, Rankinen Tuomo, Bouchard Claude
School of Physical and Health Education, Department of Community Health and Epidemiology, Queen's University, Kingston, Ontario K7L 3N6, Canada.
Med Sci Sports Exerc. 2003 Oct;35(10):1703-9. doi: 10.1249/01.MSS.0000089337.73244.9B.
To determine the efficacy of exercise training in treating the metabolic syndrome.
The sample included 621 black and white participants from the HERITAGE Family Study, identified as sedentary and apparently healthy (no chronic disease or injury). The metabolic syndrome was defined as having three or more risk factors according to the guidelines of the National Cholesterol Education Program, including elevated waist circumference, blood pressure, triglycerides, blood glucose, and low HDL cholesterol. The presence of the metabolic syndrome and component risk factors were determined before and after 20 wk of supervised aerobic exercise training.
The prevalence of the metabolic syndrome was 16.9% in this sample (105/621) of apparently healthy participants. Of the 105 participants with the metabolic syndrome at baseline, 30.5% (32 participants) were no longer classified as having the metabolic syndrome after the exercise training. Among the 32 participants who improved their metabolic profile, 43% decreased triglycerides, 16% improved HDL cholesterol, 38% decreased blood pressure, 9% improved fasting plasma glucose, and 28% decreased their waist circumference. There were no sex or race differences in the efficacy of exercise in treating the metabolic syndrome: 32.7% of men, 28.0% of women, 29.7% of black, and 30.9% of white participants with the metabolic syndrome were no longer classified as having the syndrome after training.
Aerobic exercise training in patients with the metabolic syndrome can be useful as a treatment strategy and provides support for a role for physical activity in the prevention of chronic disease.
确定运动训练对治疗代谢综合征的疗效。
样本包括来自遗传家庭研究的621名黑人和白人参与者，他们被确定为久坐不动且表面健康（无慢性病或损伤）。根据国家胆固醇教育计划的指南，代谢综合征被定义为具有三个或更多风险因素，包括腰围增加、血压升高、甘油三酯升高、血糖升高和高密度脂蛋白胆固醇降低。在进行20周的有氧锻炼训练前后，确定代谢综合征和各组成风险因素的存在情况。
在这个表面健康的参与者样本（621人中有105人）中，代谢综合征的患病率为16.9%。在基线时患有代谢综合征的105名参与者中，30.5%（32名参与者）在运动训练后不再被归类为患有代谢综合征。在改善了代谢状况的32名参与者中，43%的人甘油三酯降低，16%的人高密度脂蛋白胆固醇改善，38%的人血压降低，9%的人空腹血糖改善，28%的人腰围减小。运动治疗代谢综合征的疗效不存在性别或种族差异：患有代谢综合征的男性参与者中有32.7%、女性参与者中有28.0%、黑人参与者中有29.7%、白人参与者中有30.9%在训练后不再被归类为患有该综合征。
对代谢综合征患者进行有氧锻炼训练可作为一种治疗策略，为体育活动在预防慢性病中的作用提供了支持。
