Barcellini W, Borghi M O, Fain C, Del Papa N, Favini P, Meroni P L
Institute of Internal Medicine, University of Milan, Italy.
Int J Immunopharmacol. 1992 Oct;14(7):1279-84. doi: 10.1016/0192-0561(92)90064-r.
The effect of the non-steroidal anti-inflammatory drug (NSAID) tiaprofenic acid on different human immune parameters was investigated in vitro or following in vivo administration in healthy adult volunteers. Results from the in vitro study demonstrated an increased mitogen-induced blastogenesis and interleukin 2 (IL-2) production together with a reduced polyclonal immunoglobulin (Ig) secretion in the presence of the drug. Results from the ex vivo study showed that treatment with tiaprofenic acid had no significant effects on the immune parameters investigated, i.e. unstimulated and mitogen-induced proliferation and IL-2 production, spontaneous and stimulated Ig synthesis, lymphocyte subpopulations, serum Ig and complement levels.
在健康成年志愿者中，研究了非甾体抗炎药（NSAID）噻洛芬酸对不同人体免疫参数的影响，包括体外研究或体内给药后的情况。体外研究结果表明，在药物存在的情况下，有丝分裂原诱导的细胞增殖和白细胞介素2（IL-2）产生增加，同时多克隆免疫球蛋白（Ig）分泌减少。体外研究结果显示，噻洛芬酸治疗对所研究的免疫参数没有显著影响，即未刺激和有丝分裂原诱导的增殖及IL-2产生、自发和刺激的Ig合成、淋巴细胞亚群、血清Ig和补体水平。
