Katial Rohit K
Division of Allergy and Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.
Immunol Allergy Clin North Am. 2003 Aug;23(3):483-99. doi: 10.1016/s0889-8561(03)00002-x.
The ubiquitous existence of cockroaches and the large-scale domestic infestation seen in inner cities make cockroach proteins a significant indoor allergen and a risk factor for asthma among inner-city residents. Studies have shown that early exposure to high levels of allergen may lead to the development of asthma in individuals with a genetic predisposition to asthma. Although field trials at cockroach abatement do not yield promising results, integrated pest management still remains the best control strategy. In highly susceptible or symptomatic patients, allergen-specific immunotherapy may be beneficial, although data are limited. As molecular techniques improve and recombinant allergens are developed, a more novel form of T-cell-specific immunotherapy may prove to be efficacious without the anaphylactic side effects seen with traditional allergy vaccines.
蟑螂的普遍存在以及在内城区出现的大规模家庭侵扰，使得蟑螂蛋白成为一种重要的室内过敏原，也是内城区居民患哮喘的一个风险因素。研究表明，早期接触高水平过敏原可能会导致有哮喘遗传易感性的个体患上哮喘。尽管蟑螂防治的现场试验没有取得令人满意的结果，但综合虫害管理仍然是最佳的控制策略。在高度易感或有症状的患者中，过敏原特异性免疫疗法可能有益，尽管相关数据有限。随着分子技术的改进和重组过敏原的研发，一种更新颖的T细胞特异性免疫疗法可能会被证明有效，且不会出现传统过敏疫苗所具有的过敏副作用。
