Segel Sally Y, Miles Annette M, Clothier Bonnie, Parry Samuel, Macones George A
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, USA.
Am J Obstet Gynecol. 2003 Sep;189(3):799-802. doi: 10.1067/s0002-9378(03)00765-8.
This study was undertaken to compare the efficacy of 3 days versus 7 days of ampicillin in prolonging gestation for at least 7 days in women with preterm premature rupture of membranes (PPROM).
We performed a randomized clinical trial comparing 3 days of ampicillin with 7 days ampicillin in patients with PPROM. Our primary outcome was the prolongation of pregnancy for at least 7 days. Secondary outcomes included rates of chorioamnionitis, postpartum endometritis, and neonatal morbidity and mortality.
Forty-eight patients were randomly selected. There was no statistically significant difference in the ability to achieve a 7-day latency (relative risk 0.83, 95% CI 0.51-1.38). In addition, there was no statistically significant difference in the rates of chorioamnionitis, endometritis, and our composite neonatal morbidity.
In patients with PPROM, length of antibiotic therapy does not change the rate of a 7-day latency or affect the rate of chorioamnionitis, postpartum endometritis, or neonatal morbidity.
本研究旨在比较氨苄西林治疗3天与7天对胎膜早破（PPROM）女性延长孕周至少7天的疗效。
我们进行了一项随机临床试验，比较了PPROM患者使用3天氨苄西林与7天氨苄西林的效果。我们的主要结局是孕周延长至少7天。次要结局包括绒毛膜羊膜炎、产后子宫内膜炎的发生率以及新生儿发病率和死亡率。
随机选取了48例患者。在实现7天潜伏期的能力方面没有统计学上的显著差异（相对风险0.83，95%置信区间0.51 - 1.38）。此外，绒毛膜羊膜炎、子宫内膜炎的发生率以及我们综合的新生儿发病率方面也没有统计学上的显著差异。
对于PPROM患者，抗生素治疗的时长不会改变7天潜伏期的发生率，也不会影响绒毛膜羊膜炎、产后子宫内膜炎的发生率或新生儿发病率。
