毒液肽的治疗潜力。

Therapeutic potential of venom peptides.

作者信息

Lewis Richard J, Garcia Maria L

机构信息

Institute for Molecular Bioscience, The University of Queensland, St. Lucia 4072, Australia.

出版信息

Nat Rev Drug Discov. 2003 Oct;2(10):790-802. doi: 10.1038/nrd1197.

DOI:10.1038/nrd1197

PMID:14526382

Abstract

Venomous animals have evolved a vast array of peptide toxins for prey capture and defence. These peptides are directed against a wide variety of pharmacological targets, making them an invaluable source of ligands for studying the properties of these targets in different experimental paradigms. A number of these peptides have been used in vivo for proof-of-concept studies, with several having undergone preclinical or clinical development for the treatment of pain, diabetes, multiple sclerosis and cardiovascular diseases. Here we survey the pharmacology of venom peptides and assess their therapeutic prospects.

摘要

有毒动物已经进化出大量用于捕食和防御的肽类毒素。这些肽针对多种药理学靶点，使其成为在不同实验范式中研究这些靶点特性的宝贵配体来源。其中一些肽已在体内用于概念验证研究，有几种已进入临床前或临床开发阶段，用于治疗疼痛、糖尿病、多发性硬化症和心血管疾病。在此，我们综述了毒液肽的药理学并评估了它们的治疗前景。