Guryanova Svetlana V, Ovchinnikova Tatiana V
M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Medical Institute, Peoples' Friendship University of Russia, 117198 Moscow, Russia.
Mar Drugs. 2025 Jul 15;23(7):288. doi: 10.3390/md23070288.
Marine peptides, derived from a great number of aquatic organisms, exhibit a broad spectrum of biological activities that hold a significant therapeutic potential. This article reviews the multifaceted roles of marine peptides, focusing on their antibacterial, antibiofilm, antifungal, antiviral, antiparasitic, cytotoxic, anticancer, immunomodulatory, chemotactic, opsonizing, anti-inflammatory, antiaging, skin-protective, and wound-healing properties. By elucidating mechanisms of their action and highlighting key research findings, this review aims to provide a comprehensive understanding of possible therapeutic applications of marine peptides, underscoring their importance in developing novel drugs as well as in cosmetology, food industry, aquatic and agriculture biotechnology. Further investigations are essential to harness their therapeutic potential and should focus on detailed mechanism studies, large-scale production, and clinical evaluations with a view to confirm their efficacy and safety and translate these findings into practical applications. It is also important to investigate the potential synergistic effects of marine peptide combinations with existing medicines to enhance their efficacy. Challenges include the sustainable sourcing of marine peptides, and therefore an environmental impact of harvesting marine organisms must be considered as well.
海洋肽来源于大量水生生物,具有广泛的生物活性,具有巨大的治疗潜力。本文综述了海洋肽的多方面作用,重点关注其抗菌、抗生物膜、抗真菌、抗病毒、抗寄生虫、细胞毒性、抗癌、免疫调节、趋化、调理、抗炎、抗老化、皮肤保护和伤口愈合特性。通过阐明其作用机制并突出关键研究发现,本综述旨在全面了解海洋肽可能的治疗应用,强调其在开发新药以及在美容、食品工业、水产和农业生物技术中的重要性。进一步的研究对于发挥其治疗潜力至关重要,应侧重于详细的机制研究、大规模生产和临床评估,以确认其疗效和安全性并将这些发现转化为实际应用。研究海洋肽与现有药物组合的潜在协同作用以提高疗效也很重要。挑战包括海洋肽的可持续来源,因此还必须考虑捕捞海洋生物对环境的影响。