一些新型取代萘醌的合成与生物学评价

Synthesis and biological evaluation of some new substituted naphthoquinones.

作者信息

Habib Nargues S, Bekhit Adnan A, Park Ji Young

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.

出版信息

Boll Chim Farm. 2003 Jun;142(5):232-8.

Abstract

Two novel series of 1,4-naphthoquinone derivatives have been synthesized namely; N-ethoxycarbonyl-2-ethoxycarbonyloxy-3- alkyl-1,4-naphthoquinon-1-substituted phenylhydrazones 3a-f and 2-chlorocetyloxy-3-alkyl-1,4-naphthoquinone-1-substituted phenylhydrazones 4a-d. The antimicrobial activity as well as anticancer activity of these compounds have been evaluated. The acute toxicity of the active compounds was determined.

摘要

已经合成了两个新型的1,4 -萘醌衍生物系列，即：N -乙氧羰基-2 -乙氧羰氧基-3 -烷基-1,4 -萘醌-1 -取代苯腙3a - f和2 -氯乙酰氧基-3 -烷基-1,4 -萘醌-1 -取代苯腙4a - d。对这些化合物的抗菌活性和抗癌活性进行了评估。测定了活性化合物的急性毒性。

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