一些2-叔氨基和2,3-二叔氨基取代的1,4-萘醌及其相关化合物的合成与药理学研究
Synthesis and pharmacological studies of some 2-t-amino and 2,3-di-t-amino substituted 1,4-naphthoquinones and related compounds.
作者信息
Tandon V K, Singh R V, Rai S, Chhor R B, Khan Z K
机构信息
Medicinal Chemistry Research Laboratory, Department of Chemistry, Lucknow University, Lucknow, India.
出版信息
Boll Chim Farm. 2002 Jul-Aug;141(4):304-10.
PMID:12426819
Abstract
Series of 2-t-amino and 2,3-di-t-amino substituted-1,4-naphthoquinones have been synthesised from corresponding 1,4-naphthoquinones by reaction with secondary amines. The compounds have been evaluated for their broad spectrum antimicrobial, antiviral and anticancer activity. In the preliminary screening results 8a and 9a have shown profile of an antimicrobial agent.
摘要
通过与仲胺反应，由相应的1,4-萘醌合成了一系列2-叔氨基和2,3-二叔氨基取代的-1,4-萘醌。已对这些化合物的广谱抗菌、抗病毒和抗癌活性进行了评估。在初步筛选结果中，8a和9a显示出抗菌剂的特性。
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