Fritsch P, Dudoignon N, Guillet K, Oghiso Y, Morlier J P, Monchaux G
Laboratoire de Radiotoxicologie, CEA/DSV/DRR, BP 12, 91680 Bruyères le Châtel, France.
Radiat Prot Dosimetry. 2003;105(1-4):149-52. doi: 10.1093/oxfordjournals.rpd.a006211.
A comparison of incidence of lung tumours in rats after inhalation exposure to aerosols containing alpha emitters which have different physico-chemical properties has been performed. Aerosols of radon and progeny, uranium ore dust, NpO2, PuO2 or Cm2O3 were considered for intercomparison with similar or different particle sizes. Dose-effect relationships for the frequency of malignant lung tumours appear linear up to a few Gy and then become infralinear at higher doses delivered to the lungs. The initial slope of the curves reflects the risk of induction of a lung tumour. The highest slopes of incidence were observed for radon and uranium ore dust (about 70 and 20% Gy(-1) respectively) for which the most homogeneous alpha dose distribution to the lungs is expected. In a general trend, increasing the alpha-activity of deposited particles (higher specific activity of constituent radioisotopes or larger particle size) decreases the risk. The comparison of the reported data shows that the risk per Gy at 'low doses' could vary over more than one order of magnitude depending on the physico-chemical properties of the aerosols.
已对大鼠吸入含有不同物理化学性质的α发射体的气溶胶后肺部肿瘤的发生率进行了比较。考虑将氡及其子体、铀矿粉尘、二氧化镎、二氧化钚或三氧化二锔的气溶胶进行相互比较，这些气溶胶的粒径相似或不同。肺部恶性肿瘤发生频率的剂量效应关系在剂量达到几戈瑞之前呈线性，然后在肺部接受更高剂量时变为亚线性。曲线的初始斜率反映了诱发肺部肿瘤的风险。对于氡和铀矿粉尘，观察到最高的发生率斜率（分别约为70%和20% Gy⁻¹），预计它们对肺部的α剂量分布最为均匀。总体趋势是，沉积颗粒的α活度增加（组成放射性同位素的比活度更高或粒径更大）会降低风险。对报告数据的比较表明，“低剂量”下每戈瑞的风险可能因气溶胶的物理化学性质而相差一个多数量级。
