Stabin Michael G
Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA.
J Nucl Med. 2004 Apr;45(4):634-5.
Placental transfer and fetal dose estimates have been published for women in early pregnancy and at the end of each trimester for a large number of radiopharmaceuticals. For the case of (18)F-FDG, a dose was given with no information about placental transfer of the radiopharmaceutical. Recent publications have reported quantitative values for maternal and fetal uptake of (18)F-FDG in primates and new values for (18)F-FDG kinetics. In this article, these data are applied to give radiation dose estimates for the fetus at all stages of pregnancy for (18)F-FDG. The recommended values are 2.2 x 10(-2) mGy/MBq in early pregnancy, 2.2 x 10(-2) mGy/MBq at 3-mo gestation, 1.7 x 10(-2) mGy/MBq at 6-mo gestation, and 1.7 x 10(-2) mGy/MBq at 9-mo gestation.
对于大量放射性药物，已经公布了早孕期及各孕期末期女性的胎盘转运和胎儿剂量估算值。对于（18）F-FDG的情况，给药时未提供有关该放射性药物胎盘转运的信息。最近的出版物报道了灵长类动物母体和胎儿摄取（18）F-FDG的定量值以及（18）F-FDG动力学的新值。在本文中，这些数据被用于给出（18）F-FDG在孕期各个阶段对胎儿的辐射剂量估算值。推荐值为早孕期2.2×10（-2）mGy/MBq，妊娠3个月时2.2×10（-2）mGy/MBq，妊娠6个月时1.7×10（-2）mGy/MBq，妊娠9个月时1.7×10（-2）mGy/MBq。
