Kar K, Puri V N, Patnaik G K, Sur R N, Dhawan B N, Kulshrestha D K, Rastogi R P
J Pharm Sci. 1975 Feb;64(2):258-262. doi: 10.1002/jps.2600640213.
Himachalol has been identified as the major antispasmodic constituent in the wood of Cedrus deodara. The pharmacological studies of himachalol on various isolated smooth muscles (guinea pig ileum, rabbit jejunum, rat uterus, and guinea pig seminal vesicle) and against different agonists (acetylcholine, histamine, serotonin, nicotine, and barium chloride) indicated spasmolytic activity similar to that of papaverine. It was a more potent antagonist of barium chloride-induced spasm of guinea pig ileum than papaverine but less effective in reverting a similar spasm of rabbit jejunum and had no relaxing effect alone. In the conscious immobilized cat, intragastric administration of himachalol or papaverine (100 mg/kg) produced equal inhibition of carbachol-induced spasm of the intestine, lasting about 2 hr, but himachalol had a faster onset of action. Himachalol was devoid of spasmolytic effect on the bronchial musculature of guinea pig but was 3.3 times more potent than papaverine in antagonizing epinephrine-induced contraction of the guinea pig seminal vesicle. Intravenous injection of himachalol (3-10 mg/kg) in the cat produced a dose-dependent fall in blood pressure and an increased femoral blood flow.
雪松醇已被确定为喜马拉雅雪松木材中的主要解痉成分。对雪松醇在各种离体平滑肌（豚鼠回肠、兔空肠、大鼠子宫和豚鼠精囊）上以及针对不同激动剂（乙酰胆碱、组胺、5-羟色胺、尼古丁和氯化钡）的药理研究表明，其具有与罂粟碱相似的解痉活性。在拮抗氯化钡诱导的豚鼠回肠痉挛方面，它比罂粟碱更有效，但在缓解兔空肠类似痉挛方面效果较差，且单独使用无松弛作用。在清醒固定的猫中，胃内给予雪松醇或罂粟碱（100毫克/千克）对卡巴胆碱诱导的肠痉挛产生同等程度的抑制，持续约2小时，但雪松醇起效更快。雪松醇对豚鼠支气管肌肉组织无解痉作用，但在拮抗肾上腺素诱导的豚鼠精囊收缩方面比罂粟碱强3.3倍。在猫中静脉注射雪松醇（3 - 10毫克/千克）会导致血压呈剂量依赖性下降以及股血流量增加。
