Boedefeld William M, Bland Kirby I, Heslin Martin J
Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35243, USA.
Ann Surg Oncol. 2003 Oct;10(8):839-51. doi: 10.1245/aso.2003.02.021.
The numerous studies profiling mechanisms in colorectal carcinoma have implicated multiple pathways in the malignant progression of a colorectal epithelial cell. Such pathways as aberrations in the cell cycle, deviation from apoptosis, neovascularization of tumors, and invasion and metastasis of malignant epithelial cells have been shown to occur in the progression of a normal epithelial cell to an adenoma and carcinoma. Today, we continue to search for communications or connections between these pathways as we try to get a more global picture of the events responsible for the adenoma-carcinoma sequence. This review focuses on the latest developments of three well-characterized pathways implicated in colorectal carcinoma: angiogenesis, apoptosis, and invasion and metastasis. We will attempt to highlight clinical correlates, when available, with some of the more interesting molecules.
众多对结直肠癌机制进行剖析的研究表明，多种途径参与了结直肠上皮细胞的恶性进展。诸如细胞周期异常、凋亡偏离、肿瘤新生血管形成以及恶性上皮细胞的侵袭和转移等途径，已被证实在正常上皮细胞向腺瘤和癌的进展过程中会发生。如今，在我们试图更全面地了解导致腺瘤 - 癌序列的事件时，仍在继续探寻这些途径之间的联系。本综述聚焦于结直肠癌中三个已被充分阐明的途径的最新进展：血管生成、凋亡以及侵袭和转移。我们将尝试突出临床相关性（若有）以及一些更有趣的分子。
