Atkin G K, Chopada A
Department of Surgery, Ealing Hospital NHS Trust, Middlesex, UK.
Ann R Coll Surg Engl. 2006 Oct;88(6):525-9. doi: 10.1308/003588406X117106.
Angiogenesis is the process of new blood vessel formation from pre-existing vessels, and is a key feature of malignant tumours. Surgeons involved in the management of patients with malignant disease need to be aware of angiogenic mechanisms and their surgical implications.
A literature search was used to review recent developments in our understanding of the factors and processes involved in tumour angiogenesis, and how these will impact on the care of patients with malignant disease encountered by surgeons.
Angiogenesis is fundamental to all stages of the malignant process, and involves a complex interaction between mediators secreted by tumour cells and host cells. Intense investigation continues into therapies targeting components of the angiogenic cascade. Imaging modalities capable of measuring the angiogenic activity of a tumour are also being studied in order to predict prognosis and select suitable patients for anti-angiogenic therapy.
As the use of these anti-angiogenic therapies becomes more wide-spread, they may have implications on the healing rates of cutaneous wounds and intracorporeal anastomoses.
血管生成是指从已有的血管形成新血管的过程，是恶性肿瘤的一个关键特征。参与恶性疾病患者管理的外科医生需要了解血管生成机制及其手术意义。
通过文献检索回顾了我们对肿瘤血管生成所涉及的因素和过程的最新认识，以及这些因素如何影响外科医生所诊治的恶性疾病患者的护理。
血管生成是恶性肿瘤发生发展全过程的基础，涉及肿瘤细胞和宿主细胞分泌的介质之间的复杂相互作用。针对血管生成级联反应各成分的治疗研究仍在深入进行。能够测量肿瘤血管生成活性的成像方法也在研究中，以便预测预后并选择适合接受抗血管生成治疗的患者。
随着这些抗血管生成疗法的应用越来越广泛，它们可能会对皮肤伤口和体内吻合口的愈合率产生影响。
