Da Cruz Ivana Beatrice Mânica, Oliveira Graziela, Taufer Maristela, Leal Ney Furhmann, Schwanke Carla Helena, Glock Luiz, Moriguchi Yukio, Moriguchi Emilio Hideyuki
Instituto de Geriatria e Gerontologia, Pontifícia Universidade Católica do Rio Grande do Sul, Brazil.
J Gerontol A Biol Sci Med Sci. 2003 Sep;58(9):M851-6. doi: 10.1093/gerona/58.9.m851.
Several studies have been published on the association between ACE (angiotensin I-converting enzyme) polymorphism and longevity. However, the results are controversial.
We analyzed the association between ACE polymorphism and age in two different ethnic populations: a population originating from different European countries (Gaucha Population, GP) and a population originating from Japan (JP). Both populations live in Brazil's southern region.
We determined the ACE genotype in 834 persons aged 10-104 years. The ACE genotype and allele frequencies differed between the two populations, with the D allele being more frequent in GP than JP. We found an association between the DD genotype and D allele and age in the GP group only. The ACE polymorphism-age association occurred at age >60 years in the GP population with decreasing II frequency.
We cannot dismiss the possibility of the association between ACE polymorphism and age involving linkage disequilibrium, since the nature of this phenomenon is still controversial. From our studies, it appears that there is a correlation between age, ethnicity, and ACE polymorphism. More of such studies are warranted, as further investigation in this area will have a high clinical relevance to cardiovascular disease and aging research.
已有多项关于血管紧张素转换酶（ACE）基因多态性与长寿之间关联的研究发表。然而，结果存在争议。
我们分析了两个不同种族人群中ACE基因多态性与年龄之间的关联：一个来自不同欧洲国家的人群（高乔人群，GP）和一个来自日本的人群（JP）。这两个人群都生活在巴西南部地区。
我们测定了834名年龄在10至104岁之间人群的ACE基因型。两个群体的ACE基因型和等位基因频率有所不同，D等位基因在GP人群中的频率高于JP人群。我们仅在GP组中发现DD基因型和D等位基因与年龄之间存在关联。在GP人群中，ACE基因多态性与年龄的关联发生在60岁以上，且II频率降低。
由于这种现象的本质仍存在争议，我们不能排除ACE基因多态性与年龄之间的关联涉及连锁不平衡的可能性。从我们的研究来看，年龄、种族和ACE基因多态性之间似乎存在相关性。鉴于该领域的进一步研究对心血管疾病和衰老研究具有高度临床相关性，有必要开展更多此类研究。
