Faculty of Health and Sport Science, University of Zaragoza, Huesca, Spain.
Ageing Res Rev. 2013 Sep;12(4):1079-87. doi: 10.1016/j.arr.2013.04.001. Epub 2013 Apr 23.
The ACE I/D polymorphism has been associated with longevity, although not consistently. The objective of this study was to detect the possible unequal distribution of the alleles and genotypes of this polymorphism among centenarians and younger segments of the population. Relevant data were extracted from studies in the literature, comparing genotype and allele frequencies between centenarians and younger controls. The association of ACE I/D polymorphism with exceptional longevity was analyzed in a total of 1803 centenarians and 10,484 controls using the chi-square test with the Yates correction. We conducted combined analyses for all ethnic groups studied in the literature (Caucasian, Chinese and Korean) as well as for Caucasians only. The DD genotype (odds ratio (OR): 1.25 (95% confidence interval (CI): 1.02-1.54), P=0.032) and the D-allele were more frequent in Caucasian centenarians compared with their younger controls (OR: 1.16 (95% CI: 1.05-1.28), P<0.001). Similar findings were obtained when all ethnic origin groups were included in the analyses, with no evidence of publication bias or heterogeneity (P>0.05). The present meta-analysis indicates that the ACE D-allele and the DD genotype might confer a modest, albeit significant advantage to reach exceptional longevity.
ACE I/D 多态性与长寿有关，但并非一致。本研究的目的是检测该多态性等位基因和基因型在百岁老人和年轻人群中的分布是否存在差异。从文献中的研究中提取相关数据，比较了百岁老人和年轻对照组的基因型和等位基因频率。使用卡方检验（Yates 校正），总共分析了 1803 名百岁老人和 10484 名对照者 ACE I/D 多态性与异常长寿的关联。我们对文献中研究的所有种族（高加索人、中国人和韩国人）以及仅高加索人进行了联合分析。与年轻对照组相比，DD 基因型（优势比（OR）：1.25（95%置信区间（CI）：1.02-1.54），P=0.032）和 D 等位基因在高加索裔百岁老人中更为常见（OR：1.16（95% CI：1.05-1.28），P<0.001）。当将所有种族起源组纳入分析时，也得出了类似的发现，没有发表偏倚或异质性的证据（P>0.05）。本荟萃分析表明，ACE D 等位基因和 DD 基因型可能赋予达到异常长寿的适度但显著的优势。
