调控组蛋白乙酰转移酶和去乙酰化酶。
Regulating histone acetyltransferases and deacetylases.
作者信息
Legube Gaëlle, Trouche Didier
机构信息
Laboratoire de Biologie Moléculaire des Eucaryotes, UMR 5099 Centre National de la Recherche Scientifique, Institut d'Exploration Fonctionnelle des Génomes, 118 Route de Narbonne, 31062 Toulouse Cedex, France.
出版信息
EMBO Rep. 2003 Oct;4(10):944-7. doi: 10.1038/sj.embor.embor941.
Abstract
Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated in cells through the modulation of their levels, activity and availability for interaction with specific transcription factors. In this review, we present the various molecular mechanisms that bring about this tight regulation and discuss how these regulatory events influence cellular responses to environmental changes.
摘要
组蛋白乙酰转移酶和组蛋白去乙酰化酶调节组蛋白和转录因子的乙酰化，从而在细胞命运控制中发挥主要作用。最近的许多研究结果表明，它们的功能在细胞中通过调节其水平、活性以及与特定转录因子相互作用的可及性而受到严格调控。在本综述中，我们介绍了实现这种严格调控的各种分子机制，并讨论了这些调控事件如何影响细胞对环境变化的反应。
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