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本文引用的文献

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Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex.类固醇通过靶向一种HDAC1复合物刺激前脂肪细胞分化。
EMBO J. 2003 May 1;22(9):2135-45. doi: 10.1093/emboj/cdg218.
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Histone deacetylases: unique players in shaping the epigenetic histone code.组蛋白去乙酰化酶：塑造表观遗传组蛋白密码的独特因子。
Ann N Y Acad Sci. 2003 Mar;983:84-100. doi: 10.1111/j.1749-6632.2003.tb05964.x.
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P300 transcriptional repression is mediated by SUMO modification.P300转录抑制由SUMO修饰介导。
Mol Cell. 2003 Apr;11(4):1043-54. doi: 10.1016/s1097-2765(03)00141-2.
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Recruitment of p300 by C/EBPbeta triggers phosphorylation of p300 and modulates coactivator activity.C/EBPβ招募p300会触发p300的磷酸化并调节共激活因子活性。
EMBO J. 2003 Feb 17;22(4):882-92. doi: 10.1093/emboj/cdg076.
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Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases.将染色质功能与代谢网络相联系：NAD⁺依赖的去乙酰化酶Sir2家族。
Trends Biochem Sci. 2003 Jan;28(1):41-8. doi: 10.1016/s0968-0004(02)00005-1.
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MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300.丝裂原活化蛋白激酶（MAP激酶）磷酸化依赖性激活Elk-1会导致共激活因子p300的激活。
EMBO J. 2003 Jan 15;22(2):281-91. doi: 10.1093/emboj/cdg028.
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The viral control of cellular acetylation signaling.病毒对细胞乙酰化信号的调控。
Bioessays. 2003 Jan;25(1):58-65. doi: 10.1002/bies.10202.
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Activation of the mouse histone deacetylase 1 gene by cooperative histone phosphorylation and acetylation.通过协同的组蛋白磷酸化和乙酰化激活小鼠组蛋白去乙酰化酶1基因
Mol Cell Biol. 2002 Nov;22(22):7820-30. doi: 10.1128/MCB.22.22.7820-7830.2002.
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Control of CBP co-activating activity by arginine methylation.通过精氨酸甲基化对CBP共激活活性的调控。
EMBO J. 2002 Oct 15;21(20):5457-66. doi: 10.1093/emboj/cdf548.
10
Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.N-CoR共抑制因子与Tip60共激活因子复合物的交换通过核因子κB和β-淀粉样前体蛋白连接基因表达。
Cell. 2002 Jul 12;110(1):55-67. doi: 10.1016/s0092-8674(02)00809-7.

调控组蛋白乙酰转移酶和去乙酰化酶。

Regulating histone acetyltransferases and deacetylases.

作者信息

Legube Gaëlle, Trouche Didier

机构信息

Laboratoire de Biologie Moléculaire des Eucaryotes, UMR 5099 Centre National de la Recherche Scientifique, Institut d'Exploration Fonctionnelle des Génomes, 118 Route de Narbonne, 31062 Toulouse Cedex, France.

出版信息

EMBO Rep. 2003 Oct;4(10):944-7. doi: 10.1038/sj.embor.embor941.

DOI:10.1038/sj.embor.embor941
PMID:14528264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1326399/
Abstract

Histone acetyltransferases and histone deacetylases regulate the acetylation of histones and transcription factors, and in doing so have major roles in the control of cell fate. Many recent results have indicated that their function is strictly regulated in cells through the modulation of their levels, activity and availability for interaction with specific transcription factors. In this review, we present the various molecular mechanisms that bring about this tight regulation and discuss how these regulatory events influence cellular responses to environmental changes.

摘要

组蛋白乙酰转移酶和组蛋白去乙酰化酶调节组蛋白和转录因子的乙酰化，从而在细胞命运控制中发挥主要作用。最近的许多研究结果表明，它们的功能在细胞中通过调节其水平、活性以及与特定转录因子相互作用的可及性而受到严格调控。在本综述中，我们介绍了实现这种严格调控的各种分子机制，并讨论了这些调控事件如何影响细胞对环境变化的反应。