Seavey William G, Kurata John H, Cohen Richard D
Chronic Disease Epidemiology and Control Section, California Department of Health Services, 1616 Capitol Avenue, MS 7212, Sacramento, CA 94234-7320, USA.
J Rheumatol. 2003 Oct;30(10):2103-11.
This longitudinal study examined the following variables as possible risk factors for self-reported arthritis: age, sex, race, body mass index (BMI), depressive symptoms, leisure-time physical activity, cigarette use, alcohol, hypertension, diabetes mellitus, education, income, and hard physical work.
Altogether, 1149 women and 964 men from the Alameda County Study Cohort without self-reported arthritis in 1974 were assessed for incident self-reported arthritis in 1994.
In a multivariate model, the following variables were associated with increased odds of incident arthritis: increasing age (age 45-49, odds ratio 2.00, 95% confidence interval 1.40-2.85; age 50+, OR 3.13, 95% CI 2.32-4.22), BMI for women only (4th quintile, OR 1.65, 95% CI 1.05-2.60; 5th quintile, OR 1.88, 95% CI 1.19-2.95), female sex (OR 1.48, 95% CI 1.20-1.83), and >/= 5 depressive symptoms (OR 1.53, 95% CI 1.12-2.10). Leisure-time physical activity in the highest quartile was protective (OR 0.69, 95% CI 0.51-0.95). All other factors were not associated with arthritis.
This study indicates that depressive symptoms, as well as age, sex, and BMI, are independent risk factors for arthritis. This is the first longitudinal population based study to examine and establish that prior depressive symptoms are a risk factor for arthritis.
这项纵向研究考察了以下变量作为自我报告的关节炎可能的风险因素：年龄、性别、种族、体重指数（BMI）、抑郁症状、休闲时间的体力活动、吸烟、饮酒、高血压、糖尿病、教育程度、收入和繁重的体力劳动。
1974年，来自阿拉米达县研究队列的1149名女性和964名男性在当时均未自我报告患有关节炎，对他们在1994年发生的自我报告的关节炎情况进行了评估。
在多变量模型中，以下变量与关节炎发病几率增加相关：年龄增长（45 - 49岁，比值比2.00，95%置信区间1.40 - 2.85；50岁及以上，比值比3.13，95%置信区间2.32 - 4.22），仅女性的BMI（第4五分位数，比值比1.65，95%置信区间1.05 - 2.60；第5五分位数，比值比1.88，95%置信区间1.19 - 2.95），女性性别（比值比1.48，95%置信区间1.20 - 1.83），以及≥5种抑郁症状（比值比1.53，95%置信区间1.12 - 2.10）。休闲时间体力活动处于最高四分位数具有保护作用（比值比0.69，95%置信区间0.51 - 0.95）。所有其他因素与关节炎无关。
本研究表明，抑郁症状以及年龄、性别和BMI是关节炎的独立风险因素。这是第一项基于纵向人群的研究，用以考察并确定既往抑郁症状是关节炎的一个风险因素。
