Jarrett Stephen J, Cunnane Gaye, Conaghan Philip G, Bingham Sarah J, Buch Maya H, Quinn Mark A, Emery Paul
Academic Unit of Musculoskeletal Medicine, University of Leeds, Great George Street, Leeds LS1 3EX, United Kingdom.
J Rheumatol. 2003 Oct;30(10):2287-91.
As experience with anti-tumor necrosis factor (TNF-alpha) therapy increases, there has been the expected emergence of reports on uncommon side effects. Large clinical trials identified the development of autoantibodies and postmarketing surveillance has identified problems including tuberculosis. There have been several case reports of drug-induced systemic lupus erythematosus. We describe eight patients with rheumatoid arthritis treated with anti-TNF therapies who developed presumed vasculitis, with different pathophysiologic causes. We discuss the literature and potential causal mechanisms, including disease activity, the role of autoantibodies, and shifts in T cell responses.
随着抗肿瘤坏死因子（TNF-α）治疗经验的增加，关于罕见副作用的报告如预期般出现。大型临床试验发现了自身抗体的产生，上市后监测也发现了包括结核病在内的问题。已有数例药物性系统性红斑狼疮的病例报告。我们描述了8例接受抗TNF治疗的类风湿关节炎患者，他们发生了推测为血管炎的病症，病因各不相同。我们讨论了相关文献及潜在的因果机制，包括疾病活动度、自身抗体的作用以及T细胞反应的变化。
