Deloince R, Beaudry Y, Robert D, Barjox P, Le Pivert P, Fontanges R
C R Seances Soc Biol Fil. 1977;171(4):819-22.
An association of bacterial ribosomes and cell-wall of Klebsiella pneumoniae was shown to reduce the incidence of an epidermoid carcinoma in Sprague-Dawley rats when administered subcutaneously prior the tumoral graft. Mononuclear cells accumulate around the tumor. This association was considered as a non specific adjuvant stimulating the host's intrinsic immunity to tumor antigens.
研究表明，肺炎克雷伯菌的细菌核糖体与细胞壁的结合物在肿瘤移植前皮下给药时，可降低斯普拉格-道利大鼠表皮样癌的发病率。单核细胞在肿瘤周围聚集。这种结合物被认为是一种非特异性佐剂，可刺激宿主对肿瘤抗原的固有免疫。
