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福源口服液增强肠道功能的药效学研究

[Pharmacodynamics study of Fuyuan oral liqiuid on enhancing intestinal function].

作者信息

Yi Quan, Peng Fei, Wei Yi, Luo Miaoshan

机构信息

Guangzhou Medical College, Guangzhou 510182.

出版信息

Zhong Yao Cai. 2003 Jun;26(6):417-20.

Abstract

OBJECTIVE

To observe the effect of Fuyuan oral liquid (FYOL) on mice and rats intestinal function.

METHOD

The effect of FYOL on the carbo-dust drive distance in mice whose intestinal function is normal or weakened by atropine was determined. The effect of FYOL on rats intestional movement curves and mesenteric microcirculation was determined. The effect of FYOL on the inflammatory exudation due to aceti acid in mice was determined.

RESULT

FYOL increased mice intestinal drive distance regardless of function normal or weakened by atropine. FYOL increased rats intestional peristalsis intensity but not fequency and ameliorates mesenteric microcirculation. FYOL inhibited mice inflammatory exudation by acetic acid.

CONCLUSION

FYOL can accelerate intestinal peristalsis and ameliorate mesenteric microcirculation and anti-inflammation.

摘要

目的

观察复元口服液(FYOL)对小鼠和大鼠肠道功能的影响。

方法

测定FYOL对肠道功能正常或因阿托品而减弱的小鼠炭末推进距离的影响。测定FYOL对大鼠肠道运动曲线和肠系膜微循环的影响。测定FYOL对小鼠醋酸所致炎症渗出的影响。

结果

无论肠道功能正常还是因阿托品而减弱,FYOL均增加小鼠肠道推进距离。FYOL增加大鼠肠道蠕动强度但不增加频率,并改善肠系膜微循环。FYOL抑制小鼠醋酸所致炎症渗出。

结论

FYOL可促进肠道蠕动、改善肠系膜微循环并具有抗炎作用。

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