[低剂量亚硝基甲基脲对静止细胞群体的作用。一项实验与建模]
[The action of low doses of nitrosomethylurea on a stationary cell population. An experiment and modelling].
作者信息
Krutova T V, Chernikova S B, Konradov A A, Burlakova E B
出版信息
Izv Akad Nauk SSSR Biol. 1992 Jul-Aug(4):511-8.
PMID:1452900
Abstract
The change of stationary cell population (murine spleen) following an exposure to low doses of methylnitrosourea (10(-11)-10(-5) g/kg of mouse weight) was investigated and modelled mathematically. The suggested model is based on the idea that the effect of cytotoxic agent in low doses has nondestructive "signal" character, changing dynamic balance between cells in proliferating and quiescent compartments.
摘要
研究了低剂量甲基亚硝基脲（10⁻¹¹ - 10⁻⁵ g/kg小鼠体重）暴露后静止细胞群体（小鼠脾脏）的变化，并进行了数学建模。所提出的模型基于这样一种观点，即低剂量细胞毒性剂的作用具有非破坏性的“信号”特征，改变了增殖和静止区室中细胞之间的动态平衡。
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