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[不同小鼠品系脾细胞对烷化化合物抗增殖作用的敏感性]

[Sensitivity of the splenic cells of different mouse strains to the antiproliferative action of alkylating compounds].

作者信息

Pukhal'skiĭ A L, Mezhneva A P, Pevnitskiĭ L A

出版信息

Biull Eksp Biol Med. 1988 Feb;105(2):196-8.

PMID:3349150
Abstract

A method of quantitative evaluation of lymphocytes' sensitivity to the antiproliferative effect of the alkylating drugs has been developed. Chlorbutin, mafosfamide (Asta Z 7654) and "active" metabolites of cyclophosphamide were studied. This research allowed to distinguish more sensitive strains (DBA/2 and C57BL/6) and those with low sensitivity (BALB/c and CC57BR). These differences do not depend on proliferation reaction, neither on the type of alkylating drugs nor haplotypes H-2.

摘要

已开发出一种定量评估淋巴细胞对烷化剂抗增殖作用敏感性的方法。研究了氯布替林、马磷酰胺（Asta Z 7654）和环磷酰胺的“活性”代谢产物。该研究能够区分出更敏感的品系（DBA/2和C57BL/6）以及低敏感性的品系（BALB/c和CC57BR）。这些差异既不取决于增殖反应，也不取决于烷化剂的类型或H-2单倍型。

相似文献

1
[Sensitivity of the splenic cells of different mouse strains to the antiproliferative action of alkylating compounds].[不同小鼠品系脾细胞对烷化化合物抗增殖作用的敏感性]
Biull Eksp Biol Med. 1988 Feb;105(2):196-8.
2
[Comparative study of mechanisms of antiproliferative action of low concentrations of mafosfamide and cyclosporin A].[低浓度马法兰与环孢素A抗增殖作用机制的比较研究]
Biull Eksp Biol Med. 1993 May;115(5):514-5.
3
[Sensitivity of the splenic immunocompetent cells of mice with different genotypes to the action of alkylating agents].[不同基因型小鼠脾脏免疫活性细胞对烷化剂作用的敏感性]
Biull Eksp Biol Med. 1985 Aug;100(8):213-5.
4
[Genetic heterogeneity of heat shock protein synthesis and sensitivity of spleen cells to the antiproliferative effect of alkylating agents in mice].[小鼠热休克蛋白合成的遗传异质性及脾细胞对烷化剂抗增殖作用的敏感性]
Biull Eksp Biol Med. 1997 Nov;124(11):561-5.
5
[Variability of the sensitivity of human lymphocytes to the antiproliferative action of alkylating agents].[人类淋巴细胞对烷化剂抗增殖作用敏感性的变异性]
Biull Eksp Biol Med. 1983 May;95(5):73-5.
6
[Effect of cyclophosphane, chlorbutin and degranol on protein biosynthesis in the lymphocytes of donors and chronic lympholeukemia patients in vitro].[环磷酰胺、苯丁酸氮芥及丙酰苄胺氮芥对供体及慢性淋巴细胞白血病患者淋巴细胞蛋白质生物合成的体外作用]
Eksp Onkol. 1985;7(1):52-5.
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[Degree of proliferative response to concanavalin A of spleen cells of mice of different strains and production of interleukin-2].[不同品系小鼠脾细胞对刀豆蛋白A的增殖反应程度及白细胞介素-2的产生]
Biull Eksp Biol Med. 1989 Aug;108(8):238-40.
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[Genetic differences in mice in the sensitivity to the immunodepressive action of alkylating agents].[小鼠对烷化剂免疫抑制作用敏感性的遗传差异]
Biull Eksp Biol Med. 1983 Apr;95(4):79-81.
9
Immunosuppressive action of cyclophosphamide in mice: contribution of some factors to determination of strain differences.环磷酰胺对小鼠的免疫抑制作用：某些因素对品系差异测定的影响
Int J Immunopharmacol. 1993 May;15(4):509-14. doi: 10.1016/0192-0561(93)90065-7.
10
Survival of hematopoietic and lymphoma colony-forming cells in vivo following the administration of a variety of alkylating agents.给予多种烷化剂后造血和淋巴瘤集落形成细胞在体内的存活情况。
Cancer Res. 1972 Mar;32(3):470-6.

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