Park Joo-In, Tsai Sophia Y, Tsai Ming-Jer
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Keio J Med. 2003 Sep;52(3):174-81. doi: 10.2302/kjm.52.174.
Chicken ovalbumin upstream promoter-transcription factors (COUP-TFs) are one of the most characterized orphan receptors of the steroid/thyroid hormone receptor superfamily. COUP-TFs play important roles in the regulation of organogenesis, neurogenesis, and cellular differentiation during embryonic development. COUP-TFs were generally considered to be repressors of transcription, however, there are growing evidences that COUP-TFs can function as transcription activators. Here we will review the molecular mechanism of COUP-TFs as repressors and activators. Also, we will review the known biological function of COUP-TFI during development and differentiation.
鸡卵清蛋白上游启动子转录因子（COUP-TFs）是类固醇/甲状腺激素受体超家族中特征最为明确的孤儿受体之一。COUP-TFs在胚胎发育过程中的器官发生、神经发生和细胞分化调控中发挥着重要作用。COUP-TFs通常被认为是转录抑制因子，然而，越来越多的证据表明COUP-TFs可以作为转录激活因子发挥作用。在此，我们将综述COUP-TFs作为抑制因子和激活因子的分子机制。此外，我们还将综述COUP-TFI在发育和分化过程中已知的生物学功能。
