Orsetti A, Hagelsteen C, Zouari N
C R Seances Soc Biol Fil. 1977;171(4):858-64.
Islets of Langerhans were stablished in the spaces between 9 synthetic hollowfibers in a "bio-artificial insulin distributor" which was implanted in the carotid artery of totally pancreatectomized dogs. Normo-glycemia was restored after 4 hours. The major problem encountered was coagulation in the fibers. Presently, this limits the prolonged utilization of this system.