Orsetti A, Guy C, Zouari N, Deffay R
C R Seances Soc Biol Fil. 1978;172(1):144-50.
In the diabetic dog, the implantation of a bioartificial insulin distributor (Biard) producted a temporary normoglycemia, using islets of Langerhans isolated from dog pancreas and cultured on the outer surface of the hollow fibers (XM 50). In a diabetic dog receiving the Biard using porcine isolated islets, the hyperglycemia was partially corrected during two days. In a diabetic dog due to implantation of human isolated islets the slight rise of insulin and human C-peptide is not accompanied by significant decrease in hyperglycemia. However, in another diabetic dog the Biard implantation of human islets provoked a significant increase of insulin and human C-peptide in the blood, with partial normalisation of hyperglycemia during two days.
在糖尿病犬中，植入生物人工胰岛素分配器（Biard）可产生短暂的血糖正常，该分配器使用从犬胰腺分离并在中空纤维（XM 50）外表面培养的胰岛。在一只接受使用猪分离胰岛的Biard的糖尿病犬中，血糖过高在两天内得到部分纠正。在一只因植入人分离胰岛而患糖尿病的犬中，胰岛素和人C肽略有升高，但血糖过高并未显著降低。然而，在另一只糖尿病犬中，植入人胰岛的Biard导致血液中胰岛素和人C肽显著增加，血糖过高在两天内部分恢复正常。
