Spencer H, Norris C, Osis D
Metabolic Research, Veterans Administration Hospital, Hines, Illinois 60141.
J Am Coll Nutr. 1992 Oct;11(5):561-6. doi: 10.1080/07315724.1992.10718262.
In a previous study dietary supplementation with 140 mg zinc (Zn) as Zn sulfate (ZnSO4) per day significantly decreased absorption of calcium (Ca) during a low Ca intake (230 mg/day) but not during a normal Ca intake (800 mg/day). The purpose of the present study was to determine whether smaller doses of Zn would also inhibit Ca absorption during the 230 mg Ca intake, and whether the 140 mg dose of Zn would inhibit Ca absorption during a Ca intake less than 800 mg/day. To investigate the first aspect, 100 mg Zn as ZnSO4, was given daily during a low Ca intake (230 mg/day) in six studies, and in the second phase, 140 mg Zn as ZnSO4 was given during a Ca intake of of 500 mg/day in five studies. Intestinal absorption of Ca was determined with tracer doses of 47CaCl2 in control studies and in the two Zn supplementation studies. Results showed that 100 mg Zn/day during a low Ca intake (230 mg/day) did not inhibit Ca absorption and that 140 mg Zn given during the 500 mg Ca intake also did not affect the absorption of Ca.
在先前的一项研究中，每天补充140毫克硫酸锌形式的锌，在低钙摄入量（230毫克/天）期间显著降低了钙的吸收，但在正常钙摄入量（800毫克/天）期间则没有。本研究的目的是确定较小剂量的锌在230毫克钙摄入量期间是否也会抑制钙的吸收，以及140毫克剂量的锌在钙摄入量低于800毫克/天期间是否会抑制钙的吸收。为了研究第一个方面，在六项研究中，在低钙摄入量（230毫克/天）期间每天给予100毫克硫酸锌形式的锌，在第二阶段，在五项研究中，在钙摄入量为500毫克/天期间给予140毫克硫酸锌形式的锌。在对照研究以及两项锌补充研究中，用微量的氯化钙测定钙的肠道吸收。结果表明，在低钙摄入量（230毫克/天）期间每天100毫克锌不会抑制钙的吸收，在500毫克钙摄入量期间给予140毫克锌也不会影响钙的吸收。
