Spencer H, Rubio N, Kramer L, Norris C, Osis D
J Am Coll Nutr. 1987 Feb;6(1):47-51. doi: 10.1080/07315724.1987.10720165.
Pharmacologic doses of zinc are widely used as zinc supplements. As calcium and zinc may compete for common absorption sites, a study was carried out on the effect of a pharmacologic dose of zinc on the intestinal absorption of calcium in adult males. The analyzed dietary zinc intake in the control studies was normal, averaging 14.6 mg/day. During the high zinc study, 140 mg zinc as the sulfate was added daily for time periods ranging from 17 to 71 days. The studies were carried out during both a low calcium intake averaging 230 mg/day and during a normal calcium intake of 800 mg/day. Calcium absorption studies were carried out during the normal and high zinc intake by using an oral tracer dose of Ca47 and determining plasma levels and urinary and fecal excretions of Ca47. The study has shown that, during zinc supplementation, the intestinal absorption of calcium was significantly lower during a low calcium intake than in the control study, 39.3% vs 61% respectively, p less than 0.001. However, during a normal calcium intake of 800 mg/day, the high zinc intake had no significant effect on the intestinal absorption of calcium. These studies have shown that the high zinc intake decreased the intestinal absorption of calcium during a low calcium intake but not during a normal calcium intake.
药理剂量的锌被广泛用作锌补充剂。由于钙和锌可能竞争共同的吸收位点，因此对成年男性进行了一项关于药理剂量的锌对钙肠道吸收影响的研究。对照研究中分析的膳食锌摄入量正常，平均为14.6毫克/天。在高锌研究期间，每天添加140毫克硫酸锌，持续时间为17至71天。研究在低钙摄入量平均为230毫克/天和正常钙摄入量800毫克/天的情况下进行。通过口服Ca47示踪剂量并测定Ca47的血浆水平以及尿液和粪便排泄量，在正常和高锌摄入量期间进行钙吸收研究。研究表明，在补充锌期间，低钙摄入量时钙的肠道吸收明显低于对照研究，分别为39.3%和61%，p小于0.001。然而，在正常钙摄入量800毫克/天的情况下，高锌摄入量对钙的肠道吸收没有显著影响。这些研究表明，高锌摄入量在低钙摄入量时会降低钙的肠道吸收，但在正常钙摄入量时不会。
