Coudray Charles, Rambeau Mathieu, Feillet-Coudray Christine, Tressol Jean Claude, Demigne Christian, Gueux Elyett, Mazur Andrzej, Rayssiguier Yves
Centre de Recherche en Nutrition Humaine d'Auvergne, Unité Maladies Métaboliques et Micro-nutriments, INRA, Theix, 63122 St-Genès-Champanelle, France.
Nutr J. 2005 Oct 27;4:29. doi: 10.1186/1475-2891-4-29.
previous studies have shown that non-digestible inulin-type fructan intake can increase intestinal mineral absorption in both humans and animals. However, this stimulatory effect on intestinal absorption may depend on experimental conditions such as duration of fermentable fiber intake, mineral diet levels and animals' physiological status, in particular their age.
the aim of this study was to determine the effect of inulin intake on Ca and Mg absorption in rats at different age stages.
eighty male Wistar rats of four different ages (2, 5, 10 and 20 months) were randomized into either a control group or a group receiving 3.75% inulin in their diet for 4 days and then 7.5% inulin for three weeks. The animals were fed fresh food and water ad libitum for the duration of the experiment. Intestinal absorption of Ca and Mg was determined by fecal monitoring using stable isotopic tracers. Ca and Mg status was also assessed.
absorption of Ca and Mg was significantly lower in the aged rats (10 and 20 mo) than in the young and adult rat groups. As expected, inulin intake increased Ca and Mg absorption in all four rat groups. However, inulin had a numerically greater effect on Ca absorption in aged rats than in younger rats whereas its effect on Mg absorption remained similar across all four rat age groups.
the extent of the stimulatory effect of inulin on absorption of Ca may differ according to animal ages. Further studies are required to explore this effect over longer inulin intake periods, and to confirm these results in humans.
先前的研究表明，摄入不可消化的菊粉型果聚糖可增加人和动物肠道对矿物质的吸收。然而，这种对肠道吸收的刺激作用可能取决于实验条件，如可发酵纤维摄入的持续时间、矿物质饮食水平以及动物的生理状态，尤其是年龄。
本研究旨在确定菊粉摄入对不同年龄阶段大鼠钙和镁吸收的影响。
80只不同年龄（2、5、10和20个月）的雄性Wistar大鼠被随机分为对照组或饮食中摄入3.75%菊粉4天，然后摄入7.5%菊粉3周的组。在实验期间，动物可随意进食新鲜食物和水。使用稳定同位素示踪剂通过粪便监测来测定钙和镁的肠道吸收情况。同时也评估了钙和镁的状态。
老年大鼠（10和20个月）对钙和镁的吸收显著低于年轻和成年大鼠组。正如预期的那样，菊粉摄入增加了所有四个大鼠组的钙和镁吸收。然而，菊粉对老年大鼠钙吸收的影响在数值上大于年轻大鼠，而其对镁吸收的影响在所有四个大鼠年龄组中保持相似。
菊粉对钙吸收的刺激作用程度可能因动物年龄而异。需要进一步研究以探索在更长菊粉摄入期的这种影响，并在人类中证实这些结果。
