一种研究阿尔茨海默病的血清遗传学方法（作者译）
[A serogenetic approach to the study of Alzheimer's disease (author's transl)].
作者信息
Mehne P, Grünwald P, Gerner-Beuerle E
出版信息
Aktuelle Gerontol. 1976 Jun;6(6):259-66.
PMID:14530
Abstract
The analysis of 15 hereditary controlled blood characteristics in 57 Alzheimer-patients revealed abnormalities in the distribution of ABO-blood-groups and phenotypes in the third component of complement system. These data indicate that the phenogenesis of the Alzheimer syndrome is multiconditional and is obviously influenced by selective processes of immuno-genetic factors. This selective vulnerability offers a lead into the elucidation of amyloid deposition in Alzheimer's disease.
摘要
对57名阿尔茨海默病患者的15种遗传控制的血液特征进行分析后发现，ABO血型分布及补体系统第三成分的表型存在异常。这些数据表明，阿尔茨海默综合征的发病机制是多条件的，且明显受免疫遗传因素的选择性过程影响。这种选择性易损性为阐明阿尔茨海默病中的淀粉样蛋白沉积提供了线索。
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