Sawicki A, Regula A, Godwod K, Debinski A
Mineral Metabolism and Bone Diseases Unit, National Food and Nutrition Institute, Powsinska Street 61/63, 02-903, Warsaw, Poland.
Osteoporos Int. 2003 Dec;14(12):983-6. doi: 10.1007/s00198-003-1459-3. Epub 2003 Oct 3.
Low dietary intake and decreased absorption of calcium are known as important risk factors of osteoporosis. Peptic ulcer disease may be accompanied by dietary restrictions influencing negatively calcium intake. Inflammation of gastric and duodenal mucosa as well as alkali used may significantly decrease calcium absorption. Additionally, bone metabolism may be changed by inflammatory mediators released as a result of mucosal inflammation.
Comparison of bone mineral density and calcium dietary intake in women with and without (control group) peptic ulcer disease.
Two hundred and sixty-three women were studied: 143 (mean age 60.3 years) with peptic ulcer disease diagnosed by endoscopy and/or upper gastrointestinal X-ray, and 120 (mean age 58.4 years) as controls. History of alimentary tract diseases and presence of risk factors of osteoporosis, as well as history of hormone replacement therapy, were collected based on specially designed questionnaires. Women with present risk factors of secondary osteoporosis and with previously diagnosed osteoporosis were excluded. The calcium dietary intake was determined using a standard questionnaire assessing milk and milk products intake as well as calcium supplementation when used. Bone mineral density of the lumbar spine and femoral bone was determined by DXA.
Women with peptic ulcer disease not using hormone replacement therapy had lower bone mineral density in all studied regions as compared to control group without peptic ulcer disease. In the subgroup not using hormone replacement therapy all studied values differed significantly. In the smaller subgroup of women using hormone replacement therapy not all values were statistically significant. There was no statistical significance between studied groups in dietary calcium intake as milk, milk products, and calcium supplements.
Calcium intake in women with ulcer disease is similar to healthy subjects. Peptic ulcer disease is an independent risk factor for osteoporosis in women.
饮食中钙摄入量低和钙吸收减少是已知的骨质疏松症重要危险因素。消化性溃疡疾病可能伴有饮食限制，对钙摄入量产生负面影响。胃和十二指肠黏膜炎症以及所使用的碱可能会显著降低钙的吸收。此外，黏膜炎症释放的炎症介质可能会改变骨代谢。
比较患有和未患有（对照组）消化性溃疡疾病的女性的骨矿物质密度和钙饮食摄入量。
对263名女性进行了研究：143名（平均年龄60.3岁）经内镜检查和/或上消化道X线诊断为消化性溃疡疾病，120名（平均年龄58.4岁）作为对照组。根据专门设计的问卷收集消化道疾病史、骨质疏松症危险因素的存在情况以及激素替代治疗史。排除存在继发性骨质疏松症当前危险因素和先前诊断为骨质疏松症的女性。使用评估牛奶和奶制品摄入量以及使用钙补充剂情况的标准问卷来确定钙饮食摄入量。通过双能X线吸收法（DXA）测定腰椎和股骨的骨矿物质密度。
未使用激素替代治疗的消化性溃疡疾病女性在所有研究区域的骨矿物质密度均低于无消化性溃疡疾病的对照组。在未使用激素替代治疗的亚组中，所有研究值均有显著差异。在使用激素替代治疗的较小女性亚组中，并非所有值都具有统计学意义。在饮食钙摄入量方面，即牛奶、奶制品和钙补充剂方面，研究组之间无统计学意义。
溃疡病女性的钙摄入量与健康受试者相似。消化性溃疡疾病是女性骨质疏松症的独立危险因素。
