Menei P, Benoit J P
Department of Neurosurgery, Universitaire d'Angers, Angers Cedex, France.
Acta Neurochir Suppl. 2003;88:51-5. doi: 10.1007/978-3-7091-6090-9_9.
Our group have developed a new method of drug delivery into the brain using implantable biodegradable microspheres. In this mini-review, we describe the development, preclinical studies and clinical trials involving 5-fluorouracil-releasing microspheres for interstitial radiosensitization of malignant glioma. Future developments concerning these microspheres for treatment of brain tumors are presented.
我们的团队开发了一种利用可植入的可生物降解微球将药物输送到大脑的新方法。在这篇小型综述中，我们描述了用于恶性胶质瘤间质放射增敏的5-氟尿嘧啶释放微球的研发、临床前研究和临床试验。还介绍了这些微球在治疗脑肿瘤方面的未来发展情况。
