Interleukin 6 receptor as a target for the treatment of rheumatoid arthritis.
作者信息
Choy E
机构信息
Academic Department of Rheumatology, GKT School of Medicine, King's College Hospital, London, UK.
出版信息
Ann Rheum Dis. 2003 Nov;62 Suppl 2(Suppl 2):ii68-9. doi: 10.1136/ard.62.suppl_2.ii68.
Abstract
摘要
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本文引用的文献
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Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial.抗白细胞介素-6受体单克隆抗体阻断白细胞介素-6活性在类风湿关节炎中的治疗益处：一项随机、双盲、安慰剂对照、剂量递增试验。
Arthritis Rheum. 2002 Dec;46(12):3143-50. doi: 10.1002/art.10623.
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Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys.抗人白细胞介素-6受体人源化抗体可抑制食蟹猴胶原性关节炎的发展。
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Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis.白细胞介素6基因敲除小鼠对抗原诱导的实验性关节炎具有抗性。
Cytokine. 1999 Dec;11(12):1057-64. doi: 10.1006/cyto.1999.0502.
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Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis.白细胞介素-6受体的阻断改善了小鼠胶原诱导性关节炎中的关节疾病。
Arthritis Rheum. 1998 Dec;41(12):2117-21. doi: 10.1002/1529-0131(199812)41:12<2117::AID-ART6>3.0.CO;2-P.
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The use of knockout mice to understand the role of cytokines in fever.
Clin Exp Pharmacol Physiol. 1998 Feb;25(2):141-4. doi: 10.1111/j.1440-1681.1998.tb02193.x.
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Repeat treatment of rheumatoid arthritis patients with a murine anti-intercellular adhesion molecule 1 monoclonal antibody.
Arthritis Rheum. 1997 May;40(5):849-53. doi: 10.1002/art.1780400511.
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Gp130 and the interleukin-6 family of cytokines.糖蛋白130与白细胞介素-6细胞因子家族
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Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation.类风湿关节炎患者滑液中的白细胞介素-6和可溶性白细胞介素-6受体是破骨细胞样细胞形成的原因。
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