Section of Rheumatology, Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Rheumatologic and Immunologic Disease, Cleveland Clinic, Cleveland, OH, USA.
Rheumatology (Oxford). 2018 Nov 1;57(11):1885-1895. doi: 10.1093/rheumatology/kex391.
RA is a chronic, systemic, autoimmune disease characterized by inflammation and degradation of the joints, causing significant negative impact on quality of life. In addition to joint disease, symptoms and co-morbidities associated with RA-namely pain, fatigue and mood disorders-are often as debilitating as the disease itself. The pro-inflammatory cytokine IL-6 plays a critical role in RA-associated pathology. However, a greater understanding of the translational effects of IL-6 outside of the immune system is needed. This review discusses our current understanding of emerging aspects of IL-6 in RA-associated pain, fatigue and mood disorders such as depression and anxiety. This review also describes the clinical effects of IL-6 inhibition on these symptoms and co-morbidities in patients with RA.
类风湿关节炎是一种慢性、全身性、自身免疫性疾病，其特征为炎症和关节退化，对生活质量造成重大负面影响。除关节疾病外，类风湿关节炎相关的症状和合并症（如疼痛、疲劳和情绪障碍）往往与疾病本身一样具有致残性。促炎细胞因子白细胞介素 6（IL-6）在类风湿关节炎相关病理中起着关键作用。然而，我们需要更深入地了解 IL-6 在免疫系统之外的转化作用。这篇综述讨论了我们目前对 IL-6 在类风湿关节炎相关疼痛、疲劳和情绪障碍（如抑郁和焦虑）中的新兴作用的理解。这篇综述还描述了 IL-6 抑制对类风湿关节炎患者这些症状和合并症的临床效果。
