Miyasaki S H, Hicks J B, Greenspan D, Polacheck I, MacPhail L A, White T C, Agabian N, Greenspan J S
Department of Stomatology, University of California, San Francisco 94143-0512.
J Acquir Immune Defic Syndr (1988). 1992 Oct;5(10):1039-46.
Restriction fragment polymorphism analysis was used to investigate the identity and genotypic relatedness of Candida albicans strains isolated from human immunodeficiency virus (HIV)-infected patients with or without oral candidiasis and from some of their sexual partners. Use of the species-specific DNA probe Ca3 revealed that most subjects carried a single distinct C. albicans strain throughout the course of the study, during both symptomatic and asymptomatic periods. Sexual partners were more likely to carry the same or similar C. albicans isolates than unrelated subjects, raising the possibility of transmission via intimate contact. One patient appeared to acquire his partner's isolate, which then became predominant in both partners in subsequent isolations. These findings indicate that recurrent oral candidiasis is usually caused by a single persistent strain unique to each patient, but that in some cases transmission via intimate contact may occur between sexual partners.
采用限制性片段多态性分析，以研究从患有或未患有口腔念珠菌病的人类免疫缺陷病毒（HIV）感染患者及其部分性伴侣中分离出的白色念珠菌菌株的一致性和基因型相关性。使用种特异性DNA探针Ca3显示，在整个研究过程中，大多数受试者在有症状和无症状期间均携带单一独特的白色念珠菌菌株。性伴侣比无亲属关系的受试者更有可能携带相同或相似的白色念珠菌分离株，这增加了通过亲密接触传播的可能性。一名患者似乎获得了其伴侣的分离株，该分离株随后在后续分离中在双方体内都占主导地位。这些发现表明，复发性口腔念珠菌病通常由每个患者特有的单一持续菌株引起，但在某些情况下，性伴侣之间可能会通过亲密接触发生传播。
