Joki-Erkkilä Veli-Pekka, Karjalainen Jussi, Hulkkonen Janne, Pessi Tanja, Nieminen Markku M, Aromaa Arpo, Klaukka Timo, Hurme Mikko
Department of Otorhinolaryngology, Tampere University Hospital, Tampere, Finland.
Ann Allergy Asthma Immunol. 2003 Sep;91(3):275-9. doi: 10.1016/S1081-1206(10)63530-2.
Allergic rhinitis is a chronic inflammatory disease with a genetic background. Inflammatory reactions are regulated by cytokines. Cytokine genes are polymorphic and have been implicated as candidate genes in allergy.
To study the significance of the interleukin 1 (IL-1) gene complex in allergic rhinitis.
Population-based, cross-sectional study. We studied the polymorphisms of 3 IL-1 gene complex genes, IL1A (+4845G>T), IL1B (-511 degrees C>T), and IL1RN (variable number of tandem repeats; IVS2, 86 bp, duplicates 2 to 5), in patients with allergic rhinitis. The study group consisted of 405 nonasthmatic individuals of whom 56 had allergic rhinitis.
The genotype distribution differed significantly in all cytokine genes studied between subjects with and without allergic rhinitis. The difference was mainly due to an increased number of IL1A allele G homozygotes (67.9% vs 43.2%; odds ratio [OR], 2.8; 95% confidence interval [CI], 1.5-5.1), IL1B heterozygotes (72.2% vs 47.4%; OR, 2.8; 95% CI, 1.5-5.3), and IL1RN allele 2 homozygotes (18.5% vs 7.5%; OR, 2.8; 95% CI, 1.3-6.2) in allergic rhinitis. Haplotype analysis revealed a significant difference in the distribution of IL-1 gene complex haplotypes between subjects with and without allergic rhinitis (P = 0.005, 10 df).
The IL-1 gene complex polymorphism is strongly associated with allergic rhinitis in nonasthmatic individuals.
变应性鼻炎是一种具有遗传背景的慢性炎症性疾病。炎症反应由细胞因子调节。细胞因子基因具有多态性，并且已被认为是变应性疾病的候选基因。
研究白细胞介素1（IL-1）基因复合体在变应性鼻炎中的意义。
基于人群的横断面研究。我们研究了变应性鼻炎患者中3个IL-1基因复合体基因，即IL1A（+4845G>T）、IL1B（-511C>T）和IL1RN（串联重复序列可变数目；IVS2，86bp，重复2至5次）的多态性。研究组由405名非哮喘个体组成，其中56人患有变应性鼻炎。
在所有研究的细胞因子基因中，有和没有变应性鼻炎的受试者之间的基因型分布存在显著差异。差异主要是由于变应性鼻炎患者中IL1A等位基因G纯合子数量增加（67.9%对43.2%；优势比[OR]，2.8；95%置信区间[CI]，1.5 - 5.1）、IL1B杂合子数量增加（72.2%对47.4%；OR，2.8；95%CI，1.5 - 5.3）以及IL1RN等位基因2纯合子数量增加（18.5%对7.5%；OR，2.8；95%CI，1.3 - 6.2）。单倍型分析显示，有和没有变应性鼻炎的受试者之间IL-1基因复合体单倍型分布存在显著差异（P = 0.005，10自由度）。
IL-1基因复合体多态性与非哮喘个体的变应性鼻炎密切相关。
