Lee Heung-Man, Park Sook Ah, Chung Seung-Won, Woo Jeong Soo, Chae Sung Won, Lee Sang Hag, Kang Hee Joon, Hwang Soon Jae
Department of Otorhinolaryngology-Head and Neck Surgery, Communication Disorder Institute of Medical Science Research Center, Korea University College of Medicine, Seoul, South Korea.
Int J Pediatr Otorhinolaryngol. 2006 Jun;70(6):1085-8. doi: 10.1016/j.ijporl.2005.11.006. Epub 2006 Jan 6.
Allergic rhinitis is a chronic inflammatory disease with a genetic background, and IL-18 (formerly IFN-gamma-inducing factor) is a well-known pro-inflammatory cytokine. The aim of this study was to investigate whether the IL-18/-607 promoter polymorphisms were associated with allergic rhinitis in the Korean population.
Prospective study.
Deoxyribonucleic acid was obtained from the blood samples of 160 Korean children with allergic rhinitis and from 166 healthy controls. The IL-18/-607 polymorphism was analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis.
The frequency of the AC genotype of the IL-18/-607 gene polymorphism was significantly greater in allergic rhinitis patients than in controls (P<0.05).
The A allele in the IL-18/-607 gene promoter region may be involved in the development of allergic rhinitis in the Korean population.
变应性鼻炎是一种具有遗传背景的慢性炎症性疾病，而白细胞介素-18（以前称为γ干扰素诱导因子）是一种众所周知的促炎细胞因子。本研究的目的是调查白细胞介素-18 / -607启动子多态性是否与韩国人群的变应性鼻炎相关。
前瞻性研究。
从160名患有变应性鼻炎的韩国儿童和166名健康对照者的血液样本中获取脱氧核糖核酸。通过聚合酶链反应和限制性片段长度多态性（PCR-RFLP）分析来分析白细胞介素-18 / -607多态性。
变应性鼻炎患者中白细胞介素-18 / -607基因多态性的AC基因型频率显著高于对照组（P<0.05）。
白细胞介素-18 / -607基因启动子区域中的A等位基因可能与韩国人群变应性鼻炎的发生有关。
