Ley K
Department of Physiology, Freie Universitaet Berlin, Germany.
J Reconstr Microsurg. 1992 Nov;8(6):495-503. doi: 10.1055/s-2007-1006736.
Leukocyte adhesion and emigration are controlled by soluble mediators and effected by various adhesion molecules. Currently, three major families of adhesion receptors are known to contribute to this process: integrins, vascular selectins, and immunoglobulin-like receptors. These adhesion systems are not additive and mutually replaceable, but appear to constitute a cascade of events. Leukocyte margination is followed by rolling, firm adhesion, emigration, and migration in the interstitial space. In addition, biomechanical parameters like leukocyte deformability and shear stress exerted by the flowing blood modulate the efficacy of adhesive interaction. This article briefly reviews the molecular nature, biologic regulation, and physiologic function of pertinent adhesion receptors.
白细胞黏附和移出受可溶性介质控制，并受多种黏附分子影响。目前已知有三大类黏附受体家族参与这一过程：整合素、血管选择素和免疫球蛋白样受体。这些黏附系统并非相加和相互替代的，而是似乎构成了一系列事件。白细胞靠边之后依次是滚动、牢固黏附、移出以及在间质空间内迁移。此外，诸如白细胞可变形性和流动血液施加的剪切应力等生物力学参数会调节黏附相互作用的效力。本文简要综述相关黏附受体的分子本质、生物学调控及生理功能。
