一些新型2-α-L-阿拉伯吡喃糖基-1,2,4-三嗪作为潜在抗肿瘤化疗药物的合成
Synthesis of some new 2-alpha-L-arabinopyranosyl-1,2,4-triazines as potential antitumor chemotherapeutics.
作者信息
Mansour Abdel Kader, Eid Mohga M, Khalil Nasser S A M
机构信息
Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2003 Sep;22(9):1805-23. doi: 10.1081/NCN-120023274.
PMID:14533883
Abstract
Synthetic routes towards different 2-alpha-L-arabinopyranosyl-3-thioxo-2,3-dihydro-1,2,4-triazin-5(4H)-/ones or thiones were investigated. Primary human anticancer screening of two selected compounds resulted in an active compound against SF-268 (CNS) cell line.
摘要
研究了合成不同的2-α-L-阿拉伯吡喃糖基-3-硫代-2,3-二氢-1,2,4-三嗪-5(4H)-酮或硫酮的路线。对两种选定化合物进行的初步人体抗癌筛选产生了一种对SF-268（中枢神经系统）细胞系有活性的化合物。
相似文献
1
Synthesis of some new 2-alpha-L-arabinopyranosyl-1,2,4-triazines as potential antitumor chemotherapeutics.一些新型2-α-L-阿拉伯吡喃糖基-1,2,4-三嗪作为潜在抗肿瘤化疗药物的合成
Nucleosides Nucleotides Nucleic Acids. 2003 Sep;22(9):1805-23. doi: 10.1081/NCN-120023274.
2
Selective synthesis and reactions of 6-substituted-2-beta-galactosyl-1,2,4-triazines of potential anticancer activity.具有潜在抗癌活性的6-取代-2-β-半乳糖基-1,2,4-三嗪的选择性合成与反应
Nucleosides Nucleotides Nucleic Acids. 2003;22(1):21-44. doi: 10.1081/NCN-120018621.
3
4
5
6
Synthesis, crystal structure and anticancer activity of novel derivatives of ethyl 1-(4-oxo-8-aryl-4,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazin-3-yl)formate.1-(4-氧代-8-芳基-4,6,7,8-四氢咪唑并[2,1-c][1,2,4]三嗪-3-基)甲酸乙酯新型衍生物的合成、晶体结构及抗癌活性
Eur J Med Chem. 2006 Apr;41(4):539-47. doi: 10.1016/j.ejmech.2006.01.016. Epub 2006 Mar 20.
7
Synthesis and anticancer activity of novel 2-amino-4-(4-phenylpiperazino)- 1,3,5-triazine derivatives.新型2-氨基-4-(4-苯基哌嗪基)-1,3,5-三嗪衍生物的合成与抗癌活性
Acta Pol Pharm. 2004 Nov-Dec;61(6):461-6.
8
Synthesis and biological activity of 1,2,4-triazinotriazinone derivatives.1,2,4-三嗪并三嗪酮衍生物的合成与生物活性
Pharmazie. 1995 Nov;50(11):726-9.
9
Synthesis, anti-HIV and anticancer activities of new 4-(2-mercaptobenzenesulfonyl)perhydro-1,2,4-triazin-3-ones.
Acta Pol Pharm. 1998 Nov-Dec;55(6):481-6.
10
Synthesis of some N-galactosides of 3-aryl-5-benzyl (or substituted benzyl)-1,2,4-triazin-6(1H)-/ones or thiones of expected biological activity.
Nucleosides Nucleotides Nucleic Acids. 2003 Sep;22(9):1825-33. doi: 10.1081/NCN-120023275.
Zotero 插件