一些新型1,6-二氢-3-取代-6-螺-(9'-芴基)-1,2,4-三嗪-5-(4H)-酮作为潜在抗HIV和抗癌药物的合成
Synthesis of some new 1,6-dihydro-3-substituted 6-spiro-(9'-fluorene)-1,2,4-triazin-5-(4H)-ones as potential anti HIV and anticancer drugs.
作者信息
Abdel-Rahman R M, Seada M, Fawzy M, el-Baz I
机构信息
Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt.
出版信息
Pharmazie. 1994 Oct;49(10):729-33.
PMID:7816899
Abstract
1,6-Dihydro-3(2H)-thioxo-6-spiro-(9'-fluorene)-1,2,4-triazin -5(4H)-one (1) has been used to synthesize several analogous compounds via nucleophilic substitution reactions. Spectroscopic data are given in support of the proposed structures. Some of the new products possessed good anti HIV and anticancer activities.
摘要
1,6-二氢-3(2H)-硫代-6-螺-(9'-芴基)-1,2,4-三嗪-5(4H)-酮(1)已被用于通过亲核取代反应合成几种类似化合物。给出了光谱数据以支持所提出的结构。一些新产品具有良好的抗艾滋病毒和抗癌活性。
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