Cabbad M, Kofinas A, Simon N, King K, Lyttle E
York Hospital, Pennsylvania.
J Reprod Med. 1992 Sep;37(9):794-8.
In this study on the effect of fetal growth impairment < or = 25th percentile on the transverse cerebellar diameter and its relationship with other fetal biometric parameters, the sample comprised 50 women with singleton pregnancies referred for ultrasound evaluation because of clinically suspected intrauterine growth retardation. The cerebellar diameter of asymmetrically growth-impaired fetuses remained within the normal range although it was found to be reduced when compared with that of normal fetuses (4.4 +/- 0.9 versus 4.8 +/- 0.7, P < .05). Although other biometric parameters (biparietal diameter, femur length and abdominal and head circumferences) were also reduced in growth-impaired fetuses, the ratios of these biometric parameters to cerebellar diameter were similar to those of unaffected fetuses. Fetal weight was affected to a greater extent than the cerebellar diameter, leading to discordance between the two parameters. This discordance identified almost all asymmetrically growth-impaired fetuses with a sensitivity of 95.6% and specificity of 96.3%. In contrast, the ratio of head circumference to abdominal circumference remained normal in more than half of the fetuses. Fetal weight-to-cerebellar diameter discordance is a very sensitive and specific indicator of asymmetrical fetal growth impairment.
在这项关于胎儿生长受限（小于或等于第25百分位数）对小脑横径的影响及其与其他胎儿生物测量参数关系的研究中，样本包括50名单胎妊娠女性，她们因临床怀疑胎儿宫内生长迟缓而被转诊进行超声评估。生长不对称受限胎儿的小脑直径虽与正常胎儿相比减小（4.4±0.9对4.8±0.7，P<.05），但仍在正常范围内。尽管生长受限胎儿的其他生物测量参数（双顶径、股骨长度、腹围和头围）也减小，但这些生物测量参数与小脑直径的比值与未受影响胎儿相似。胎儿体重比小脑直径受影响程度更大，导致这两个参数不一致。这种不一致识别出几乎所有生长不对称受限胎儿，敏感性为95.6%，特异性为96.3%。相比之下，超过半数胎儿的头围与腹围比值仍正常。胎儿体重与小脑直径的不一致是胎儿不对称生长受限的一个非常敏感和特异的指标。
