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[布加综合征的介入放射学、血管成形术及经颈静脉肝内门体分流术]

[Interventional radiology, angioplasty and TIPS in Budd-Chiari syndrome].

作者信息

Núñez O, de la Cruz G, Molina J, Borrego G M, Marín I, Ponferrada A, Catalina V, Echenagusia A, Bañares R

机构信息

Servicio de Aparato Digestivo. Hospital General Universitario Gregorio Marañón. Madrid. España.

出版信息

Gastroenterol Hepatol. 2003 Oct;26(8):461-4. doi: 10.1016/s0210-5705(03)70394-x.

DOI:10.1016/s0210-5705(03)70394-x
PMID:14534016
Abstract

INTRODUCTION

Budd-Chiari syndrome consists of complete or partial obstruction of the hepatic veins. Many treatment options are available; new interventional radiology techniques may play an important role as an alternative to surgical shunting.

PATIENTS AND METHOD

Of 11 patients diagnosed with Budd-Chiari syndrome, 7 were treated with percutaneous balloon angioplasty or transjugular intrahepatic portosystemic shunt (TIPS) (2 and 5 patients, respectively). The efficacy of both techniques in the treatment of this syndrome was evaluated.

RESULTS

Two patients presented significant isolated stenosis of a suprahepatic vein and underwent percutaneous balloon angioplasty. In both patients outcome was favorable with resolution of ascites. Five patients underwent TIPS and four showed clinical improvement with significant reduction in Child-Pugh score (p < 0.05) and resolution of ascites. No shunt malfunction was detected during follow-up. One patient showed no improvement after placement of TIPS and died soon after the procedure and a further two died from their underlying disease during follow-up.

CONCLUSIONS

Treatment of Budd-Chiari syndrome requires multidisciplinary evaluation and should be individualized. In patients with Budd-Chiari syndrome uncontrolled by medical therapy, TIPS may become the decompressive method of choice as an alternative to surgical shunting. Liver transplantation may be reserved to patients in whom these techniques are ineffective.

摘要

引言

布加综合征是指肝静脉完全或部分阻塞。有多种治疗选择;新的介入放射学技术作为手术分流的替代方法可能发挥重要作用。

患者与方法

在11例被诊断为布加综合征的患者中,7例分别接受了经皮球囊血管成形术或经颈静脉肝内门体分流术(TIPS)(分别为2例和5例)。评估了这两种技术治疗该综合征的疗效。

结果

2例患者出现肝上静脉显著孤立性狭窄并接受了经皮球囊血管成形术。两名患者的腹水均消退,预后良好。5例患者接受了TIPS,4例临床症状改善,Child-Pugh评分显著降低(p < 0.05),腹水消退。随访期间未检测到分流功能障碍。1例患者在放置TIPS后无改善,术后不久死亡,另外2例在随访期间死于基础疾病。

结论

布加综合征的治疗需要多学科评估,应个体化。对于药物治疗无法控制的布加综合征患者,TIPS可能成为替代手术分流的首选减压方法。肝移植可用于这些技术无效的患者。

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