sup-9、sup-10和unc-93可能编码一种双孔钾通道的组成部分，该通道协调秀丽隐杆线虫的肌肉收缩。
sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans.
作者信息
de la Cruz Ignacio Perez, Levin Joshua Z, Cummins Claudia, Anderson Philip, Horvitz H Robert
机构信息
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Department of Biology, Cambridge, Massachusetts 02139, USA.
出版信息
J Neurosci. 2003 Oct 8;23(27):9133-45. doi: 10.1523/JNEUROSCI.23-27-09133.2003.
Abstract
Genetic studies of sup-9, unc-93, and sup-10 strongly suggest that these genes encode components of a multi-subunit protein complex that coordinates muscle contraction in Caenorhabditis elegans. We cloned sup-9 and sup-10 and found that they encode a two-pore K+ channel and a novel transmembrane protein, respectively. We also found that UNC-93 and SUP-10 colocalize with SUP-9 within muscle cells, and that UNC-93 is a member of a novel multigene family that is conserved among C. elegans, Drosophila, and humans. Our results indicate that SUP-9 and perhaps other two-pore K+ channels function as multiprotein complexes, and that UNC-93 and SUP-10 likely define new classes of ion channel regulatory proteins.
摘要
对sup-9、unc-93和sup-10的遗传学研究强烈表明，这些基因编码一种多亚基蛋白复合物的组成部分，该复合物协调秀丽隐杆线虫的肌肉收缩。我们克隆了sup-9和sup-10，发现它们分别编码一个双孔钾通道和一种新型跨膜蛋白。我们还发现UNC-93和SUP-10在肌肉细胞内与SUP-9共定位，并且UNC-93是一个新型多基因家族的成员，该家族在秀丽隐杆线虫、果蝇和人类中保守。我们的结果表明，SUP-9以及可能的其他双孔钾通道作为多蛋白复合物发挥作用，并且UNC-93和SUP-10可能定义了新的离子通道调节蛋白类别。
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