Görgülü Aşkin, Simşek Osman, Cobanoğlu Sabahattin, Imer Murat, Parsak Turgay
Department of Neurosurgery, Suleyman Demirel University School of Medicine, Isparta, Turkey.
Neurosurg Rev. 2004 Jul;27(3):181-4. doi: 10.1007/s10143-003-0310-9. Epub 2003 Oct 8.
Numerous materials have been used to prevent epidural scar tissue after lumbar disc surgery. Free fat grafts are common both experimentally and clinically, but there is some doubt about their protection against fibrosis, and some complications have been reported. In this prospective study, the usefulness of free fat grafts during lumbar disc surgery was evaluated. Ninety-nine patients who had undergone operation due to lumbar disc herniation were divided in two groups: those with implantation of free fat grafts (group A) and those without (group B). Outcome was evaluated at a mean of 2.6 years postoperatively according to the following criteria: visual analog scale for back and leg pain, Hannover Questionnaire on activities of daily living, reflex findings, sensory and motor deficits, consumption of analgesics, walking distance, straight leg raising test, and clinical examination. The outcome variables showed no significant differences between the two groups ( P>0.05). This study suggests that the use of free fat grafts during lumbar disc surgery was clinically ineffective.
为预防腰椎间盘手术后硬膜外瘢痕组织形成，人们已使用了多种材料。游离脂肪移植在实验和临床中都很常见，但对于其预防纤维化的作用存在一些疑问，并且已有一些并发症的报道。在这项前瞻性研究中，对腰椎间盘手术中游离脂肪移植的效用进行了评估。99例因腰椎间盘突出症接受手术的患者被分为两组：植入游离脂肪移植的患者（A组）和未植入的患者（B组）。术后平均2.6年时，根据以下标准评估结果：背部和腿部疼痛的视觉模拟量表、汉诺威日常生活问卷、反射检查结果、感觉和运动功能障碍、镇痛药使用情况、步行距离、直腿抬高试验以及临床检查。两组的结果变量无显著差异（P>0.05）。这项研究表明，腰椎间盘手术中使用游离脂肪移植在临床上并无效果。
