Landolsi Amel, Tarmiz Hasna, Ben Fatma Leila, Kallel Lamia, Gharbi Olfa, Kraïem Chakib, Korbi Sadok, Ben Ahmed Slim
Service Médecine Carcinologique, Hôpital Farhat Hached Sousse.
Tunis Med. 2003 Jun;81(6):419-24.
Primary germ cell tumours of the mediastinum are rare. We report a retrospective study of six cases. Sex ratio was 2/1. The tumor site was the posterior mediastinum in two patients and anterior in the remaining cases. High level serum markers was noted in two patients. At histologic exam we found two cases of seminoma, one embryonal carcinoma, one case of yolk sac tumor and two cases of composite tumor. All patients had non metastatic but locally advanced disease at diagnosis. Three patients were treated with cisplatin based chemotherapy followed by radiotherapy or surgical resection of residual masses. Only one patient is still alive. As it is often reported in the literature, the prognosis of this disease is poor especially for non seminomatous tumours.
纵隔原发性生殖细胞肿瘤较为罕见。我们报告了一项对6例病例的回顾性研究。男女比例为2比1。2例患者的肿瘤位于后纵隔，其余病例位于前纵隔。2例患者血清标志物水平较高。组织学检查发现2例精原细胞瘤、1例胚胎癌、1例卵黄囊瘤和2例混合性肿瘤。所有患者在诊断时均为非转移性但局部晚期疾病。3例患者接受了以顺铂为基础的化疗，随后进行放疗或手术切除残留肿块。只有1例患者仍存活。正如文献中经常报道的那样，这种疾病的预后很差，尤其是非精原细胞瘤性肿瘤。
